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MicroMirror TIRF Demonstration at the upcoming Midwest Single Molecule Workshop at University of Iowa, June 2016


The Midwest Single-Molecule workshop will gather the leading researchers in single-molecule biophysics from all across the Midwest to share ideas, research, and resources. Mad City Labs Inc. will be sponsoring a lab tour to demonstrate the MicroMirror TIRF microscope during the workshop. If you are registered for the workshop and are interested in signing up for the lab tour, please email MWSMW-2016@healthcare.uiowa.edu with mmTIRF in the subject line.

Mad City Labs offers a MicroMirror TIRF microscopy system that enables scientists to study the ordered assembly and function of biological complexes at the single molecule level. Our MicroMirror TIRF system uses through-the-objective excitation, but replaces the dichroic mirror used in conventional TIRFM systems with two broadband micromirrors positioned at opposite edges of the back aperture of the objective lens. This illumination method enables the spatial separation of the excitation and emission pathways, eliminating the need to spectrally separate them using a dichroic mirror. By eliminating multi-band dichroic mirrors, our MicroMirror TIRF microscopy system yields the superior photon sensitivity and signal-to-noise ratios required for single molecule analyses using three or more fluorophores.

For applications requiring TIR illumination over long periods of time, Mad City Labs has also developed a TIRF-lock system. The TIRF-lock software adjusts the Z-axis position of the nanopositioner to maintain the desired TIR illumination angle.

For more information about the new Single Molecule Microscope, read the newsletter in your browser or as a PDF.


Introducing the Mad City Labs NSOM, March 2016

The MCL-NSOM is a fully operational near field scanning optical microscope. It has been built on Mad City Labs versatile RM21™ inverted optical microscope which allows users to convert between NSOM, SPM, and fluorescence optical microscopy techniques.
  • Complete inverted optical microscope
  • Six axes of motorized control
  • Closed loop nanopositioning in XYZ
  • Independent automation for fiber alignment to optical axis
  • Alignment camera and detection APD included
  • Software included


For more information about the new NSOM, read the newsletter in your browser or as a PDF.

Gravitational Waves Detected 100 Years After Einstein's Prediction, February 2016

“For the first time, scientists have observed ripples in the fabric of spacetime called gravitational waves, arriving at the earth from a cataclysmic event in the distant universe.  This confirms a major prediction of Albert Einstein’s 1915 general theory of relativity and opens an unprecedented new window onto the cosmos. Gravitational waves carry information about their dramatic origins and about the nature of gravity that cannot otherwise be obtained.  Physicists have concluded that the detected gravitational waves were produced during the final fraction of a second of the merger of two black holes to produce a single, more massive spinning black hole.  This collision of two black holes had been predicted but never observed.”

Read the full press release and the paper in Physical Review Letters.

Mad City Labs congratulates the LIGO scientific collaboration on their discovery, which will open new avenues of astrophysical research. Advanced LIGO uses Nano-MTA2 fast mirror steering nanopositioning systems as part of their auxiliary optics subsystem. The Nano-MTA2 is the lowest position noise beam steering system available.




Nanopositioner-Ready Micropositioning Stages Newsletter, January 2016


The MMP Series are nanopositioner-ready, compact, stepper motor driven micropositioning stages for high precision positioning in a variety of applications. Long range linear positioning is provided in one, two or three axis configurations with high resolution and excellent repeatability. Employing our proprietary intelligent control scheme results in exceptional stability with high native precision making the MMP Series the ideal choice for demanding motion control applications. Optional high resolution (50nm) linear encoders provide real-time feedback of the actual stage position. The included Micro-Drive™ controller has a space-saving footprint, connects to a PC via a standard USB port, and can be controlled via the supplied LabVIEW based software. Complex motion profiles can be programmed and sophisticated control parameters such as automatic acceleration and deceleration is employed to achieve high stability and native accuracy. Optional wireless gamepad control is also available. The MMP Series is compatible with a wide range of our nanopositioning systems and can be customized to your requirements.

For more information about Mad City Labs' latest nanopositioner-ready micropositioning systems, read the newsletter in your browser or as a PDF.



UHV Nanopositioning Newsletter, December 2015


Capacitive sensors perform poorly in vacuum, with performance degrading up to 60% per meter of cable length. Mad City Labs PicoQ® sensor performance does not degrade in vacuum. Our extensive and practical knowledgebase, combined with proprietary PicoQ® sensor technology, uniquely places us  to provide a standard product line of UHV nanopositioners and micropositioners and develop customized solutions with the highest performance characteristics.


For more information about Mad City Labs' latest nanopositioner-ready micropositioning systems, read the newsletter in your browser or as a PDF.



Updated SPM-M Kit with Full Line of Accessories Newsletter, September 2015


The Mad City Labs SPM-M Kit is the most affordable high resolution, closed loop AFM on the market. Now it is available with a full line of accessories for seamless instrument configuration, as shown to the left.
  • double insulated enclosure (not shown)
  • video optical microscope
  • coaxial illuminator
  • base plate for easy attachment to an optical table
  • updated Tungsten tip etching station (not shown)

MadPLL®, the instrument package that is part of the SPM-M Kit, has new additional features at the same low price!
  • Reduced thermal drift
  • Two analog inputs added to the front panel for applications with auxiliary measurement such as NSOM
  • Higher resolution probe DDS for increased probe precision and accuracy
  • Z loop output is now compatible with AR option Nano-Drive® controllers (by request)

For more information about Mad City Labs' latest nanopositioner-ready micropositioning systems, read the newsletter in your browser or as a PDF.



Nature Protocols Paper on Mad City Labs MicroMirror TIRF System


Nature Protocols has published a paper from researchers at the University of Wisconsin-Madison and Brandeis University about the colocalization single-molecule spectroscopy (CoSMoS) method for studying cellular machines using the MicroMirror TIRF system.

From the abstract: "Design and construction of a scientific microscope often requires a number of custom components and a substantial time commitment. In our protocol, we have streamlined this process by implementation of a commercially available microscopy platform designed to accommodate the optical components necessary for an mmTIRFM. The mmTIRF system eliminates the need for machining custom parts by the end user and facilitates optical alignment."

Design and construction of a multiwavelength, micromirror total internal reflectance fluorescence microscope. Larson, J. et al. Nature Protocols 9, 2317–2328 (2014)



New molecular motion tracking mode for Nano-Cyte®


The Nano-Cyte® Single Molecule Imaging system now features a "tracking" mode capable of surveying a wide sample area. This new feature builds on the existing capabilities of the Nano-Cyte® fluorescence imaging system: nanometer scale stabilization in three dimensions, image acquisition, device control, particle localization analysis, particle position rendering and active positional control.

The tracking mode is capable of surveying a 200 micron by 200 micron area within a sample, representing 16 typical fields-of-view (FOVs), while maintaining 3-dimensional stability at the nanometer scale. Using this feature it is now possible to track the motion of particles at the nanometer level as they move through multiple FOVs for extended periods of time.



Mad City Labs GmbH Opens in Zürich

Mad City Labs GmbH logoMad City Labs, Inc. is pleased to announce the opening of a direct sales office located in Zürich, Switzerland. The establishment of Mad City Labs GmbH will greatly enhance the service and support to our European customers and strengthen our relationships with our European distribution network and business partners. Please contact Mad City Labs GmbH for quotation, sales and support services.






mclgen@madcitylabs.com       phone: 608.298.0855       fax: 608.298.9525

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